Updated: 08/27/2014 14:15 | By Agence France-Presse

Japan lab unable to replicate 'stem cell' findings: report

Researchers in Japan have been unable to replicate experiments that were hailed earlier this year as a "game-changer" in the quest to grow transplant tissue, amid claims evidence was faked, a report said Wednesday.


Japan lab unable to replicate 'stem cell' findings: report

A photo released by Japan's national institute Riken on January 28, 2014 shows what is meant to be Stimulus Triggered Acquisition of Pluripotency (STAP) cells. The research has now been called into question.

In a scandal that rocked Japan's scientific establishment, Riken -- a research institute that sponsored the study -- launched an independent experiment in April to verify research published by scientist Haruko Obokata and her colleagues earlier this year.

But the struggle to replicate the experiment casts further doubt on the existence of stem cell-like cells, what the researchers called Stimulus-Triggered Acquisition of Pluripotency (STAP) cells, Japan's Nikkei daily reported.

Obokata was feted after unveiling findings that appeared to show a straightforward way to re-programme adult cells to become stem cells -- precursors that are capable of developing into any other cell in the human body.

Identifying a readily manufacturable supply of stem cells could one day help meet a need for transplant tissues, or even whole organs, meaning that any advance in the field is met with excitement in the scientific community.

But after being accused of fabricating results, she agreed to retract papers published in the respected journal Nature.

Earlier this month, Obokata's co-author, stemcell scientist Yoshiki Sasai, hanged himself.

Researchers have been trying to replicate results appearing to show that exposing ordinary cells to various stresses had made them pluripotent, or able to differentiate into any type of tissue.

Riken had planned to implant these cells into mouse embryos to test whether they really were pluripotent.

But the experiments have been fraught with difficulty from the outset, with researchers unable to reproduce such cells, the Nikkei said, citing unnamed sources. 

Obokata has been trying in tandem to reproduce her own results since July, but the existence of the STAP cells at this point looks highly doubtful, the Nikkei said.

Riken is to release an interim report on the follow-up study and announce a shake-up of the developmental biology centre in a Wednesday news conference, where it is expected to slash its staff of around 400 researchers by half.

Latest Photo Galleries on xinmsn

NEWS VIDEOS

MORE NEWS VIDEOS

facebook recommendations

LIVE NEWS RADIO STREAMING

  • 938 Live

    938LIVE is Singapore's only English news and talk station which transmits round the clock with an engaging and enticing spread of programmes on current affairs, health, business and lifestyle as well as news every half hour until midnight.

  • Capital 958


    95.8FM城市频道的前身是"第三广播网"。上个世纪30年代末,新加坡就有中文广播,一路走来经过不少政治,社会局势的改变,中文广播在本地一直扮演举足轻重的角色。